Txoj kev loj hlob ntawm tes yog ib kauj ruam tseem ceeb hauv kev lag luam biopharmaceutical.Kev ua tiav qhov ruaj khov thiab ua tau zoo ntawm cov hom phiaj proteins yog ib qho tseem ceeb rau txoj kev loj hlob ntawm tes.Qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis yog ib txoj hauv kev tseem ceeb hauv kev txhim kho kab ntawm tes, thiab nws qhov tseem ceeb tau cuam tshuam hauv cov hauv qab no:
Ua ntej, nws txhim kho gene insertion stability.Random integration thev naus laus zis yog ib txoj hauv kev zoo tshaj plaws hauv kev tsim cov kab ntawm tes, tab sis nws qhov chaw nkag tsis ruaj khov, ua rau muaj teeb meem xws li kev hloov pauv thiab poob ntawm cov noob qhia.Siv qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis tuaj yeem sib xyaw cov noob exogenous rau hauv cov haujlwm tshwj xeeb ntawm lub hom phiaj ntawm tes chromosome, ua kom muaj kev ruaj ntseg ntawm cov noob qhia thiab txo qis qhov tsis paub tseeb hauv cov txheej txheem ntawm txoj kab ntawm tes.
Qhov thib ob, nws txo cov tshuaj toxicity tshwm sim.Random kev koom ua ke thev naus laus zis tuaj yeem ua rau cov noob exogenous tau muab tso rau hauv qhov kev txhawb nqa lossis kev hloov pauv hauv cheeb tsam, ua rau muaj tshuaj lom.Qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis tuaj yeem zam qhov teeb meem no, tsis yog tsuas yog ua kom muaj kev ruaj ntseg ntawm cov noob qhia, tab sis kuj txo cov kev pheej hmoo ntawm cov tshuaj toxicity tshuaj.
Thib peb, nws txhim kho gene qhia efficiency.Siv cov cuab yeej tshwj xeeb ntawm kev sib koom ua ke, cov kab xov tooj ntawm tes ntawm cov hom phiaj tau sai sai tau los ntawm kev tshuaj ntsuam clones kev koom ua ke rau hauv lub hom phiaj ntawm qhov chaw, yog li txhim kho gene qhia efficiency.Kev nthuav qhia cov noob tau zoo yog qhov tseem ceeb los tsim cov khoom siv biologics zoo, tshwj xeeb tshaj yog rau biopharmaceuticals uas yuav tsum tau ua ntau ntau.
Plaub, nws txo cov nqi tsim khoom.Qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis tuaj yeem tswj hwm qib kev qhia ntawm lub hom phiaj cov noob, yog li tswj tau zoo dua cov txheej txheem tsim khoom thiab cov khoom lag luam zoo.Qhov no txo qis cov khoom pov tseg uas tsis tsim nyog thiab rov ua haujlwm dua, thiab tseem ua rau kev ua haujlwm ntau lawm, txo cov nqi tsim khoom.
Thib tsib, nws txhim kho cov khoom zoo.Qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis tuaj yeem tswj hwm qib kev qhia thiab qhov zoo ntawm lub hom phiaj noob, ua lub luag haujlwm tseem ceeb hauv kev tsim cov biologics zoo.Piv txwv li, lub hom phiaj ntawm qhov tsis ruaj khov thiab cleavage ntawm ib lub ntsiab lus, txo qis impurity theem, thiab ua kom ruaj khov thiab sib xws ntawm cov khoom zoo.Nws kuj tseem muab ntau txoj kev xaiv rau cov tuam txhab biopharmaceutical, ua kom lawv ua tau zoo raws li kev lag luam thiab cov neeg siv khoom xav tau.
Hauv cov ntsiab lus, siv qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis hauv kev loj hlob ntawm tes muaj txiaj ntsig zoo, suav nrog kev txhim kho cov noob kev ruaj ntseg, txo cov tshuaj lom neeg cov tshuaj tiv thaiv kab mob, txhim kho gene qhia efficiency, txo cov nqi tsim khoom, thiab txhim kho cov khoom zoo.Cov txiaj ntsig zoo no ua rau qhov chaw tshwj xeeb kev sib koom ua ke thev naus laus zis ib qho kev hloov pauv tsis tseem ceeb hauv kev lag luam biopharmaceutical.
Post lub sij hawm: Jun-01-2023